5-CHLOROBENZOTHIAZOLE Chemical Properties

Melting point:

106 °C

Boiling point:

267.8±13.0 °C(Predicted)

Density 

1.435±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Acetonitrile (Slightly), Chloroform (Slightly)

form 

Solid

pka

0.34±0.10(Predicted)

color 

Off-White to Pale Yellow

InChI

InChI=1S/C7H4ClNS/c8-5-1-2-7-6(3-5)9-4-10-7/h1-4H

InChIKey

YTSFYTDPSSFCLU-UHFFFAOYSA-N

SMILES

S1C2=CC=C(Cl)C=C2N=C1

Safety Information

HS Code 

29342000

5-CHLOROBENZOTHIAZOLE Usage And Synthesis

Chemical Properties

White solid

Uses

5-Chlorobenzo[d]thiazole is used in preparation of Hydroxyl Alkylation derivatives of Benzothiazole.

Synthesis

The general procedure for the synthesis of 5-chlorobenzo[d]thiazole from 2,5-dichlorobenzothiazole is as follows: Pd(OAc)2-PPh3, Pd2(dba)3-tbpf, Pd2(dba)3-DavePhos, Pd2(dba)3-P(t-Bu)3, Pd2(dba)3-XantPhos or Pd(OAc)2 -XPhos as catalyst systems. First, anhydrous THF (13.2 mL) was degassed by bubbling argon for a few minutes, followed by the addition of Pd(OAc)2 (7.2 mg, 0.033 mmol, 5 mol%) and PPh3 (17.7 mg, 0.132 mmol, 20 mol%) and stirring the mixture for 30 minutes at room temperature. Next, halogenated heterocycles (0.66 mmol), TMEDA (0.130 g, 1.12 mmol, 1.7 eq.) and NaBH4 (42.4 mg, 1.12 mmol, 1.7 eq.) were added sequentially. The reaction mixture was stirred at room temperature or heated under argon protection at 65 °C for an appropriate time. After completion of the reaction, the residue was dissolved in brine and extracted with ethyl acetate. The organic phase is separated, dried and the solvent is evaporated, and finally the residue is purified by fast chromatography (a solvent mixture of petroleum ether and ethyl acetate) to give the pure hydrodehalogenated heterocyclic product.

References

[1] Journal of Molecular Catalysis A: Chemical, 2014, vol. 393, p. 191 - 209

5-CHLOROBENZOTHIAZOLE(2786-51-8)Related Product Information

• IR-140
• 5-Chloro-2-methylbenzothiazole
• 4-Chloro-2-mercaptobenzothiazole
• 2-AMINO-5,6-DICHLOROBENZOTHIAZOLE
• Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI)
• 5-CHLORO-3-ETHYL-2-METHYLBENZOTHIAZOLIUM P-TOLUENESULFONATE
• 5-CHLORO-2-[(5-CHLORO-3-(4-SULFOBUTYL)-2(3H)-BENZOTHIAZOLYLIDENE)-2- METHYL- 1-PROPENYL]-3-(4-SULFOBUTYL)- BENZOTHIAZOLIUM HYDROXIDE, INNER SALT, SODIUM SALT
• (5-CHLORO-BENZOTHIAZOL-2-YLSULFANYL)-ACETIC ACID
• 2-METHYL-3-SULFOBUTYL-5-CHLOROBENZOTHIAZOLIUM, INNER SALT
• RARECHEM AL F1 4052
• 5-CHLORO-3-(3-SULFOPROPYL)-2-((3-(5-CHLORO-3-(3-SULFOPROPYL))-2-BENZOTHIAZOLINYLIDENE] METHYL)-1-BUTENYL) BENZOTHIAZOLIUM HYDROXIDE, INNER SALT
• 5-CHLORO-3-(3-SULFOPROPYL)-2-[3-(3-(5-CHLORO-3-(3-SULFOPROPYL))-2-BENZOTHIAZOLINYLIDENE]-2-METHYL-1-PROPENYL] BENZOTHIAZOLIUM HYDROXIDE, INNER SALT
• RARECHEM AL FI 0059
• 5-CHLORO-2-(3-(3-CARBOXYETHYL-5-CHLORO)-2-BENZOTHIAZOLINYLIDENE)-1-PROPENYL)-3-CARBOXYETHYL BENZOTHIAZOLIUM HYDROXIDE, INNER SALT
• 5-CHLORO-2-(2-((5-METHYL-3-CARBOXYETHYL-2-(3H)-BENZOSELENOZOZYLIDENE) METHYL)-1-BUTENYL-3-ETHYL-BENZOTHIAZOLIUM IODIDE
• 5-CHLORO-2-(2-((5,6-DIMETHYL-3-SULFOPROPYL-2(3H)-BENZOTHIAZOLYLIDENE) METHYL)-1-BUTENYL)-3-ETHYL-BENZOTHIAZOLIUM HYDROXIDE, INNERSALT
• 5-CHLORO-3-(3-SULFOPROPYL)-2-([5-CHLORO-3-(3-SULFOPROPYL)-2,3-DIHYDRO-BENZOTHIAZOL-2-YLIDENE]METHYL)BENZOTHIAZOLIUM INNER SALT TRIETHYLAMMONIUM SALT
• 5-CHLORO-2-(2-(5-CHLORO-3-(3-SULFOBUTYL)-2(3H)-BENZOTHIAZOLINYLIDENE) METHYL-1-PROPENYL)-3-(3-SULFOBUTYL) BENZOTHIAZOLIUM HYDROXIDE, INNER SALT,TRIETHYLAMINE SALT