BAY-1816032
BAY-1816032 Basic information
- Product Name:
- BAY-1816032
- Synonyms:
-
- BAY-1816032 (BAY1816032)
- BAY-1816032
- Ethanol, 2-[3,5-difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]-
- 2-[3,5-Difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]ethanol
- inhibit,BAY1816032,Inhibitor,BAY 1816032,BAY-1816032
- 2-(3,5-Difluoro-4-((3-(5-methoxy-4-((3-methoxypyridin-4-yl)amino)pyrimidin-2-yl)-1H-indazol-1-yl)methyl)phenoxy)ethan-1-ol
- BAY-1816032, 10 mM in DMSO
- CAS:
- 1891087-61-8
- MF:
- C27H24F2N6O4
- MW:
- 534.51
- Product Categories:
-
- API
- Mol File:
- 1891087-61-8.mol
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BAY-1816032 Chemical Properties
- Boiling point:
- 640.8±55.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:37.5(Max Conc. mg/mL);70.16(Max Conc. mM)
- form
- A solid
- pka
- 14.05±0.10(Predicted)
- color
- Off-white to yellow
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BAY-1816032 Usage And Synthesis
Biological Activity
BAY 1816032 is an orally active, ATP-competitive (Ki = 1.2 μM), highly potent and selective BUB1 inhibitor (IC50 = 6.1 nM with 10 μM ATP; affinity Kd = 3.3 nM/BUB1 vs 57 nM/STK10, 850 nM/DMPK2, 2.3 μM/DDR1 and >2.3 μM toward more than 390 other kinases) th at effectively targets BUB1-dependent cellular signaling (H2A-pThr120 IC50 = 29 nM post 1h treatment of nocodazole-arrested HeLa cells) and tumor cell proliferation in vitro (IC50 range from 0.5 to 5.8 μM in 43 human and mouse cancer cultures) and in human triple-negative breast xenograft models in vivo (25-50 mg/kg twice daily p.o.; SUM-149 and MDA-MB-436).
storage
Store at -20°C
BAY-1816032Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai SuperLan Chemcial Technique Centre
- Tel
- 021-2022843681 15618226720
- lucy@atkchemical.com
Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
Twochem Co.Ltd.
- Tel
- 021-58111628 15800915896
- sales@twochem.com