4-(4-FLUOROBENZOYL)-1-(4-PHENYLBUTYL)PIPERIDINE OXALATE
4-(4-FLUOROBENZOYL)-1-(4-PHENYLBUTYL)PIPERIDINE OXALATE Basic information
- Product Name:
- 4-(4-FLUOROBENZOYL)-1-(4-PHENYLBUTYL)PIPERIDINE OXALATE
- Synonyms:
-
- 4-(4-FLUOROBENZOYL)-1-(4-PHENYLBUTYL)PIPERIDINE OXALATE
- 4F 4PP OXALATE
- (4-Fluorophenyl)(1-(4-phenylbutyl)piperidin-4-yl)methanone oxalate
- selective,potentials,Inhibitor,Serotonin Receptor,4F 4PP,ketanserin,5-HT Receptor,inhibit,4F 4PP oxalate,5-HT2C,5-hydroxytryptamine Receptor,DAMGO
- 4F 4PP oxalate, 10 mM in DMSO
- CAS:
- 144734-36-1
- MF:
- C24H28FNO5
- MW:
- 429.48
- Product Categories:
-
- Serotonin receptor
- Mol File:
- Mol File
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4-(4-FLUOROBENZOYL)-1-(4-PHENYLBUTYL)PIPERIDINE OXALATE Chemical Properties
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in DMSO and to 20 mM in ethanol
- form
- Powder
- color
- White to off-white
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4-(4-FLUOROBENZOYL)-1-(4-PHENYLBUTYL)PIPERIDINE OXALATE Usage And Synthesis
Uses
4F 4PP oxalate is a selective SR-2A antagonist.
Biological Activity
A selective 5-HT 2A antagonist with almost as high affinity (K i = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT 2C sites (K i = 620 nM).
in vivo
4F 4PP (100 nM) reduces the lowest [D-ala2,N-me-phe4,gly.l5]-enkephalin (DAMGO) concentration and can produce a significant depression of evoked field potentials[1].
IC 50
5-HT2A Receptor: 5.3 nM (Ki); 5-HT2C Receptor: 620 nM (Ki)
storage
Store at RT
4-(4-FLUOROBENZOYL)-1-(4-PHENYLBUTYL)PIPERIDINE OXALATESupplier
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