CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID Chemical Properties

Melting point:

>250 °C (decomp)

Boiling point:

251.0±33.0 °C(Predicted)

Density 

1.267±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.67±0.20(Predicted)

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2916399090

CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID Usage And Synthesis

Uses

CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Azide 10a (0.30 g, 1.9 mmol) was dissolved in methanol (5 mL); then 6N HCl (2 mL) and 10% palladium on charcoal were added to the solution. The resulting mixture was stirred under 1 bar of hydrogen for 3 h, then the catalyst was filtered off, and the solvent was removed under reduced pressure. The residue was dissolvedin 6N HCl (5 mL) and refluxed upon stirring for 1 h, then evaporated in vacuum. The residue was purified by ion-exchange chromatography (Amberlite? IR-120(plus) ion-exchange resin, 3.5% aqueous ammonia as an eluent). cis-3-aminocyclobutanecarboxylic acid 1a as white powder, yield 0.16 g, 1.4 mmol, 71%.

CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID(74316-27-1)Related Product Information

• Cyclobutanecarboxylic acid
• 3-AMINOBICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID HYDROCHLORIDE
• CIS-3-BENZYLAMINOCYCLOBUTANECARBOXYLIC ACID
• Cis-3-(tert-butoxycarbonylamino)cyclobutanecarboxylic acid
• 4-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[2.1.1]HEXANE-1-CARBOXYLIC ACID
• methyl 3-aminocyclobutanecarboxylate hydrochloride
• 5-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[3.1.1]HEPTANE-1-CARBOXYLIC ACID
• 3-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID
• 1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLIC ACID
• (TRANS)-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID HYDROCHLORIDE
• CIS-3-CBZ-AMINOCYCLOBUTANECARBOXYLIC ACID
• CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID