5-METHYLBENZOXAZOLE Chemical Properties

Melting point:

41-44 °C

Boiling point:

96 °C / 15mmHg

Density 

1.1475 (rough estimate)

refractive index 

1.5320 (estimate)

Flash point:

87℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

2.66±0.10(Predicted)

color 

White to Green to Brown

CAS DataBase Reference

10531-78-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C,Xn

Risk Statements 

36/37/38-37/38-36-34-20/21/22-41-22

Safety Statements 

37/39-26-45-36/37/39-27-39-36

WGK Germany 

1

HS Code 

29349990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-METHYLBENZOXAZOLE Usage And Synthesis

Chemical Properties

YELLOW TO BROWN CRYSTALLINE SOLID

Synthesis

GENERAL METHOD: Triethyl orthoformate (1.1 mmol) and o-amino-p-toluol (1 mmol) were mixed and p-toluenesulfonic acid (TSA, 1 mol%) was added as a catalyst. The reaction mixture was stirred at 80-90 °C for an appropriate time depending on the course of the reaction (cf. Table 4). After completion of the reaction (monitored by TLC), the reaction mixture was diluted with chloroform (10 mL) and the catalyst was removed by filtration. The final product 5-methylbenzazole was purified by column chromatography.

References

[1] Monatshefte fur Chemie, 2011, vol. 142, # 1, p. 87 - 91
[2] Combinatorial Chemistry and High Throughput Screening, 2013, vol. 16, # 8, p. 618 - 627
[3] Chemical Communications, 2014, vol. 50, # 73, p. 10661 - 10664
[4] Monatshefte fur Chemie, 2007, vol. 138, # 7, p. 663 - 667
[5] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 1029 - 1034

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