18-HYDROXYCORTICOSTERONE Usage And Synthesis

Description

18-hydroxycorticosterone is a derivative of corticosterone that has a weak electrolyte action. 18-hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the aldosterone synthase in the zona glomerulosa.

Synthesis

Human CYP11B2, which catalyzes the synthesis of 18-hydroxycorticosterone, is located on chromosome 8 (8q21-q22), and consists of nine exons. Human CYP11B2 mRNA has 2935 bp, which encodes a protein of 503 residues.

Uses

18-Hydroxycorticosterone is a derivative of Corticosterone. 18-Hydroxycorticosterone is used as an intermediate in the synthesis of Aldosterone (A514700).