SALOR-INT L368539-1EA Chemical Properties

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 20mg/mL, clear

form 

powder

pka

12.96±0.70(Predicted)

color 

white to beige

InChI

1S/C19H21N5OS/c1-3-14-7-9-16(10-8-14)21-17(25)13-26-19-23-22-18(24(19)4-2)15-6-5-11-20-12-15/h5-12H,3-4,13H2,1-2H3,(H,21,25)

InChIKey

UWCCKVJVOHTHAF-UHFFFAOYSA-N

SMILES

CCC(C=C1)=CC=C1NC(CSC2=NN=C(C3=CN=CC=C3)N2CC)=O

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

SALOR-INT L368539-1EA Usage And Synthesis

Uses

VUAA1 is an insect odorant co-receptor (Orco) agonist. VUAA1 activates both heteromeric and homomeric Orco-containing channels. VUAA1 can disrupt the destructive behaviors of nuisance insects. VUAA1 can be used for insect olfactory research[1][2].

Biochem/physiol Actions

VUAA1 is an agonist of the highly conserved insect odorant receptor co-receptor ion channel Orco. VUAA1 is able to activate both heteromeric and homomeric Orco-containing channels, acting as an insect repellant by over-activating an insect′s olfactory senses causing a repellent effect.

References

[1] Corcoran JA, et al. Endogenous insensitivity to the Orco agonist VUAA1 reveals novel olfactory receptor complex properties in the specialist fly Mayetiola destructor. Sci Rep. 2018 Feb 22;8(1):3489. DOI:10.1038/s41598-018-21631-3
[2] Jones PL, et al. Functional agonism of insect odorant receptor ion channels. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8821-5. DOI:10.1073/pnas.1102425108

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