15(R)-15-METHYL PROSTAGLANDIN D2 Chemical Properties

storage temp. 

−20°C

solubility 

DMF: >100 mg/ml; DMSO: >50 mg/ml; Ethanol: >75 mg/ml; PBS (pH 7.2): >5 mg/ml

Safety Information

Hazard Codes 

T

Risk Statements 

60-22

Safety Statements 

53-22-26-36

15(R)-15-METHYL PROSTAGLANDIN D2 Usage And Synthesis

Uses

15(R)-15-Methyl prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.

Definition

ChEBI: 15-methyl-15R-PGD2 is a prostanoid.

References

[1] Hayaishi, et al. Sleep-wake regulation by prostaglandins D2 and E2. J. Biol. Chem. 263(29), 14593-14596 (1988).

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