METHYL 3,4,5-TRIMETHOXYCINNAMATE Chemical Properties

Melting point:

91-92℃

Boiling point:

371℃

Density 

1.134

Flash point:

164℃

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Safety Information

HS Code 

2916399090

METHYL 3,4,5-TRIMETHOXYCINNAMATE Usage And Synthesis

Uses

(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes[1][2].

Definition

ChEBI: Methyl-3,4,5-trimethoxy cinnamate is an alkyl cinnamate obtained by the formal condensation of the carboxy group of 3,4,5-trimethoxycinnamic acid with methanol. It is a member of methoxybenzenes and an alkyl cinnamate.

References

[1] Olajide OA, et al. Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. Inflammopharmacology. 2020 Oct;28(5):1315-1326. DOI:10.1007/s10787-020-00720-8
[2] Zhao Z, et al. Potential antiarrhythmic effect of methyl 3,4,5-trimethoxycinnamate, a bioactive substance from roots of polygalae radix: suppression of triggered activities in rabbit myocytes. Biol Pharm Bull. 2013;36(2):238-44. DOI:10.1248/bpb.b12-00654

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