N-HYDROXYBUTYRAMIDINE Chemical Properties

Boiling point:

89 °C

form 

liquid

color 

Pale brown

CAS DataBase Reference

27620-10-6

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

Hazard Note 

Harmful

HS Code 

2928009090

MSDS

• Language:English Provider:ALFA

N-HYDROXYBUTYRAMIDINE Usage And Synthesis

Description

N-hydroxybutyramidine is a kind of pharmaceutical intermediate, which can be prepared by the reaction of butyronitrile and hydroxylamine hydrochloride. It has been reported in the literature that it can be used to prepare (PI3) inhibitors.

Preparation

A solution of a mixture of butyronitrile, NaOH and hydroxylamine hydrochloride in 95% ethanol and water was refluxed Heat for 12 hours. The solvent was removed in vacuo, the oily residue was dissolved in chloroform , and insoluble NaCl was removed by filtration. The filtrate was concentrated in vacuo to give N-hydroxybutyramidine as a colorless oil.

Application

N-hydroxybutyramidine is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in the laboratory research and development process and the chemical and pharmaceutical synthesis process.

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