Lobetyolin Chemical Properties

Boiling point:

698.5±55.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

pka

11.39±0.20(Predicted)

form 

Solid

color 

White to yellow

InChIKey

MMMUDYVKKPDZHS-FHMAEMBXNA-N

SMILES

O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]([H])(/C=C/CCCO)[C@H](O)C#CC#C/C=C/C |&1:1,2,3,5,7,12,20,r|

Lobetyolin Usage And Synthesis

Uses

Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism[1][2]. Lobetyolin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] Yoon YP, et al. Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells. Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8. DOI:10.4046/trd.2014.77.5.203
[2] He W, et, al. Lobetyolin induces apoptosis of colon cancer cells by inhibiting glutamine metabolism. J Cell Mol Med. 2020 Mar;24(6):3359-3369. DOI:10.1111/jcmm.15009

Lobetyolin(129277-38-9)Related Product Information

• Lobetyolin
• Lobetyolinin