BMS-1166
BMS-1166 Basic information
- Product Name:
- BMS-1166
- Synonyms:
-
- PD-1/PD-L1-IN1
- BMS-1166 (Synonyms: PD-1/PD-L1-IN1)
- D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)-
- PD-1/PD-L1-IN1 BMS-1166
- BMS-1166 (PD-1/PD-L1-IN1)
- BMS 1166Q: What is BMS 1166 Q: What is the CAS Number of BMS 1166
- (2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid
- BMS-1166
- CAS:
- 1818314-88-3
- MF:
- C36H33ClN2O7
- MW:
- 641.11
- Mol File:
- 1818314-88-3.mol
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BMS-1166 Chemical Properties
- Boiling point:
- 817.5±65.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- form
- A crystalline solid
- pka
- 2.03±0.40(Predicted)
- color
- White to off-white
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BMS-1166 Usage And Synthesis
Biological Activity
BMS-1166 is a novel and potent inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM.
in vitro
BMS-1166 had low toxicity to the tested cell lines and prevented the interaction of soluble PD-L1 with PD-1 receptors expressed on the cell surface. It attenuates the inhibitory effect of PD-L1 on T cell receptor-mediated T lymphocyte activation.
target
| Target | Value |
| PD-1/PD-L1 interaction () | 1.4 nM |
BMS-1166Supplier
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd Gold
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- 15317229551
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
ShangHai Biochempartner Co.,Ltd
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- 17754423994 17754423994
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Shanghai Rechem science Co., Ltd.
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- 21-31433387 15618786686
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Shanghai Chaolan Chemical Technology Center
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- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com