4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE Chemical Properties

Melting point:

19-21 °C(lit.)

Boiling point:

203 °C(lit.)

Density 

1.391 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.528(lit.)

Flash point:

189 °F

storage temp. 

2-8°C

pka

5.56±0.23(Predicted)

form 

powder to lump to clear liquid

color 

White or Colorless to Yellow to Orange

FreezingPoint 

20.0 to 22.0 ℃

BRN 

168085

InChIKey

OWLPCALGCHDBCN-UHFFFAOYSA-N

CAS DataBase Reference

326-90-9(CAS DataBase Reference)

EPA Substance Registry System

1,3-Butanedione, 4,4,4-trifluoro-1-(2-furanyl)- (326-90-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29321900

4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE Usage And Synthesis

Chemical Properties

clear yellow liquid

Uses

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:

• As capping ligand in the synthesis of [Eu(tfa)₃]₂bpm complexes (bpm=2,2′-bipyrimidine).
• As reagent in the multistep synthesis of [¹³CD₂]benzylamine.
• As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.
• In the efficient syntheses of perfluoroalkyl substituted azoles.
• Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.

General Description

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated. Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria. Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated. The conformational analysis of the enol and keto form of FTFA has been reported.

4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE(326-90-9)Related Product Information

• 1-(2-FURYL)-1,3-BUTANEDIONE