HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Basic information
- Product Name:
- HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
- Synonyms:
-
- 17(20),24-trien-21-oicacid,6,16-bis(acetyloxy)-3,7-dioxo-29-nordammara-(4
- 6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-beta)--alph
- fumigacin
- HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
- (4α,8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid
- (8α,9β,13α,14β,17Z)-6β,16β-Bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid
- (8α,9β,13α,14β,17Z)-6β,16β-Diacetoxy-3,7-dioxo-29-nor-5α-dammara-1,17(20),24-trien-21-oic acid
- 29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4α,6β,8α,9β,13α,14β,16β,17Z)-
- CAS:
- 29400-42-8
- MF:
- C33H44O8
- MW:
- 568.7
- Mol File:
- 29400-42-8.mol
More
Less
HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Chemical Properties
- Melting point:
- 215°
- alpha
- D25 -121° (chloroform)
- Boiling point:
- 552.56°C (rough estimate)
- Density
- 1.1062 (rough estimate)
- refractive index
- 1.4900 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMF:30.0(Max Conc. mg/mL);52.75(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);35.17(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);35.17(Max Conc. mM) - form
- A crystalline solid
- pka
- 4.05±0.41(Predicted)
More
Less
HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS Usage And Synthesis
Description
Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.
Uses
Helvolic acid is a mycotoxin with antibacterial activity.
Definition
ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.
HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENSSupplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Lynnchem
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
Novachemistry
- Tel
- 44-20819178-90 02081917890
- info@novachemistry.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn
BOC Sciences
- Tel
- +16314854226
- inquiry@bocsci.com
More
Less
HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS(29400-42-8)Related Product Information
- 1,9-NONANEDIOL DIACETATE
- ADOXAL
- 1-DECALONE
- Isobutyroin
- 4-Methyl-3-decen-5-ol
- Geranyl acetate
- trans-2-Methyl-2-pentenoic acid
- 2-Butene-1,4-diol
- TRANS-2-OCTENOIC ACID
- 3,5,5-trimethylhexyl formate
- 3-ACETOXY-2-BUTANONE
- 2,2-DIMETHYLCYCLOHEXANONE
- 5-Hydroxy-4-octanone
- ETHYLIDENECYCLOPENTANE
- HELVOLIC ACID FROM CEPHALOSPORIUM*CAERULENS
- 9-(Z)-Tetradecen-1-ol acetate
- 3,3,5,5-TETRAMETHYLCYCLOHEXANOL
- 2-N-PROPYL-2(E)-PENTENOICACID