L-HOMOCARNOSINE FREE BASE Chemical Properties

Boiling point:

646.9±55.0 °C(Predicted)

Density 

1.327±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml

form 

A solid

pka

2.99±0.10(Predicted)

Safety Information

WGK Germany 

3

L-HOMOCARNOSINE FREE BASE Usage And Synthesis

Uses

Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1].Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].

Definition

ChEBI: A homocarnosine that has S configuration.

IC 50

Human Endogenous Metabolite

References

[1] O A Petroff, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998 Dec;44(6):948-52. DOI:10.1002/ana.410440614
[2] Thanutchaporn Kumrungsee, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020 May;52(5):743-753. DOI:10.1007/s00726-020-02848-x

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