4-CYANOPHENYLACETONITRILE 97 Chemical Properties

Melting point:

100-104 °C (lit.)

Boiling point:

180-181℃

Density 

1.056

Flash point:

71°(160°F)

refractive index 

1.499

storage temp. 

Sealed in dry,Room Temperature

form 

solid

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36

WGK Germany 

3

HS Code 

29269090

4-CYANOPHENYLACETONITRILE 97 Usage And Synthesis

Uses

4-(Cyanomethyl)benzonitrile

Synthesis

The general procedure for the synthesis of 4-cyanophenylacetonitrile from the compound (CAS: 773837-37-9) and 4-cyanobenzyl bromide is as follows: 1. Synthesis of doubly radiolabeled C3-conjugate [14C/3H]-1: a) The reaction was carried out using Na14CN (0.33 eq.) and TBAB (0.17 eq.) in a solvent mixture of CH2Cl2/H2O (1:1, v/v) at room temperature overnight. b) Subsequently, 2M NaOH (2.8 eq.) was added, followed by the addition of concentrated HCl for neutralization. 2. Synthesis of 4-(Cyanomethyl)benzonitrile (10): a) Tetrabutylammonium bromide (14 mg, 0.043 mmol, 0.5 eq.) and sodium cyanide (4.2 mg, 0.085 mmol, 1 eq.) were added to a 4 mL vial. b) Dichloromethane (1.5 mL) and water (1.5 mL) were added followed by 4-(bromomethyl)benzonitrile (0.050 g, 0.26 mmol, 3 eq.). c) The reaction system was stirred vigorously at room temperature overnight. d) After completion of the reaction, the aqueous phase was separated from the organic layer, which was extracted twice with CH2Cl2. e) The organic layers were combined and the solvent was blown dry. f) The crude product was purified by passing through a silica gel column (Pasteur pipette), eluting with 70% EtOAc/hexane to give 4-(cyanomethyl)benzylnitrile (9.2 mg, 76%) as a colorless oil, which solidified to a white solid. Product characterization data were in agreement with the literature (Velcicky, J.; Soicke, A.; Steiner, R.; Schmalz, H.-G. J. Am. Chem. Soc. 2011, 133, 6948-6951). 1H NMR (CDCl3, 500 MHz) δ 7.70 (d, 2H, J = 8.5 Hz), 7.48 (d, 2H, J = 8.5 Hz), 3.84 (s, 2H); 13C NMR (CDCl3, 151 MHz) δ 135.3, 133.0, 128.9, 118.2, 116.6, 112.5, 23.9 ; HPLC purity: 91%, tR = 1.9 min (Method 1).

References

[1] Patent: WO2016/199111, 2016, A1. Location in patent: Paragraph 00123-00126