Gypenoside L
Gypenoside L Basic information
- Product Name:
- Gypenoside L
- Synonyms:
-
- Gypenoside L
- β-D-Glucopyranoside, (2α,3β,12β)-2,12,20-trihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-
- MAPK,Extracellular signal regulated kinases,NF-κB,Nuclear factor-κB,saponin,anti-tumor,Nuclear factor-kappaB,inhibit,ERK,anti-inflammatory,Gypenoside L,Inhibitor,p38 MAPK,cytokines,p38
- CAS:
- 94987-09-4
- MF:
- C42H72O14
- MW:
- 801.02
- Mol File:
- 94987-09-4.mol
Gypenoside L Chemical Properties
- Boiling point:
- 912.3±65.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- pka
- 12.85±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- LTJZMSTVPKBWKB-XCKZQZIONA-N
Gypenoside L Usage And Synthesis
Uses
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities[1][2].
References
[1] Ma J, et, al. Gypenoside L Inhibits Proliferation of Liver and Esophageal Cancer Cells by Inducing Senescence. Molecules. 2019 Mar 18;24(6):1054. DOI:10.3390/molecules24061054
[2] Shen CY, et, al. Comparison of the Effects and Inhibitory Pathways of the Constituents from Gynostemma pentaphyllum against LPS-Induced Inflammatory Response. J Agric Food Chem. 2018 Oct 31;66(43):11337-11346. DOI:10.1021/acs.jafc.8b03903
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