Basic information Safety Supplier Related

CALCIMYCIN HEMICALCIUM SALT

Basic information Safety Supplier Related

CALCIMYCIN HEMICALCIUM SALT Basic information

Product Name:
CALCIMYCIN HEMICALCIUM SALT
Synonyms:
  • A23187 HEMICALCIUM SALT
  • 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
  • 5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
  • CALCIUM IONOPHORE A23187 HEMICALCIUM SALT
  • CALCIMYCIN A23187 HEMICALCIUM SALT
  • calcium ionophore A23187 hemicalcium
  • CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA
  • A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt
CAS:
59450-89-4
MF:
C58H72CaN6O12
MW:
1085.31
Mol File:
59450-89-4.mol
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CALCIMYCIN HEMICALCIUM SALT Chemical Properties

storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
powder
color 
yellow
BRN 
6765084
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
-
8

MSDS

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CALCIMYCIN HEMICALCIUM SALT Usage And Synthesis

Uses

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

in vivo

Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

Animal Model:Mice (ICR, 25-30 g)[5]
Dosage:2.5 or 7.5 nM
Administration:Intrapleurally
Result:Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.

CALCIMYCIN HEMICALCIUM SALTSupplier

Sigma-Aldrich
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Beijing Jin Ming Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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Hangzhou Huarong Pharm Co., Ltd.
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