15(R)-15-METHYL PROSTAGLANDIN A2 Chemical Properties

Boiling point:

520.9±50.0 °C(Predicted)

Density 

1.091±0.06 g/cm3(Predicted)

solubility 

DMF: >75 mg/ml (from PGA1); DMSO: >50 mg/ml (from PGA1); Ethanol: >100 mg/ml (from PGA1); PBS pH 7.2: >2.4 mg/ml (from PGA1)

pka

4.75±0.10(Predicted)

15(R)-15-METHYL PROSTAGLANDIN A2 Usage And Synthesis

Description

Arbaprostil (15(R)-15-methyl prostaglandin E₂) is a synthetic prostaglandin E₂ (PGE₂) analog developed for its cytoprotective activity.¹ 15(R)-15-methyl Prostaglandin A₂ (15(R)-15-methyl PGA₂) is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil.² The pharmacology and EP receptor binding affinity for 15(R)-15-methyl PGA₂ has not been published.

Definition

ChEBI: 15(R)-15-methyl Prostaglandin A2 is a prostanoid.

References

1. Collins, P.W. Misoprostol: Discovery, development, and clinical applications Med. Res. Rev. 10(2),149-172(1990).
2. Kissinger, L.D., and Robins, R.H. Silver-modified mobile phase for normal-phase liquid chromatographic determination of prostaglandins and their 5,6-trans isomers in prostaglandin bulk drugs and triacetin solutions J. Chromatogr. 321(2),353-362(1985).

15(R)-15-METHYL PROSTAGLANDIN A2(96440-68-5)Related Product Information

• 15(R)-15-METHYL PROSTAGLANDIN A2