16,16-DIMETHYL PROSTAGLANDIN A2 Chemical Properties

Boiling point:

526.9±50.0 °C(Predicted)

Density 

1.078±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: >75 mg/ml (from PGA1); DMSO: >50 mg/ml (from PGA1); Ethanol: >100 mg/ml (from PGA1); PBS pH 7.2: >2.4 mg/ml (from PGA1)

pka

4.75±0.10(Predicted)

16,16-DIMETHYL PROSTAGLANDIN A2 Usage And Synthesis

Description

16,16-dimethyl PGA₂ is a metabolism-resistant analog of PGA₂ with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 μg/ml. Daily infusion of 10 μg of 16,16-dimethyl PGA₂ methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.

Uses

16,16-dimethyl Prostaglandin A2 is a PGA2 analog studied for its antiproliferative properties.

Definition

ChEBI: 16,16-dimethyl-PGA2 is a prostanoid.

References

[1] M. G. SANTORO. Prostaglandin A Compounds as Antiviral Agents[J]. Science, 1980, 209 4460. DOI: 10.1126/science.6157190
[2] M. G. SANTORO. Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus[J]. Archives of Virology, 1988, 99 1-2: 89-100. DOI: 10.1007/bf01311026
[3] S MARINI. Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity[J]. British Journal of Cancer, 1990, 61 3: 394-399. DOI: 10.1038/bjc.1990.86

16,16-DIMETHYL PROSTAGLANDIN A2(41691-92-3)Related Product Information

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