KETOMALONIC ACID
KETOMALONIC ACID Basic information
- Product Name:
- KETOMALONIC ACID
- Synonyms:
-
- alpha-ketomalonicacid
- mesoxalate
- mesoxalicacid
- oxomalonicacid
- oxopropanedioicacid
- KETOMALONIC ACID
- 2,2-Dihydroxypropanedioic acid
- Dihydroxypropanedioic acid
- CAS:
- 473-90-5
- MF:
- C3H2O5
- MW:
- 118.04
- EINECS:
- 207-473-4
- Mol File:
- 473-90-5.mol
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KETOMALONIC ACID Chemical Properties
- Melting point:
- 178 °C
- Boiling point:
- 405.2±28.0 °C(Predicted)
- Density
- 1.832
- pka
- 1.15±0.54(Predicted)
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KETOMALONIC ACID Usage And Synthesis
Uses
Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC50 of 2.2 μM[1][2].
Definition
ChEBI: Oxomalonic acid is an oxo dicarboxylic acid. It is functionally related to a malonic acid. It is a conjugate acid of an oxomalonate(1-).
References
[1] Jean A Bernatchez, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16;290(3):1474-84. DOI:10.1074/jbc.M114.614305
[2] W R Davis, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91. DOI:10.1021/bi0015764
KETOMALONIC ACIDSupplier
Aikon International Limited
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TargetMol Chemicals Inc.
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BOC Sciences
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Shaanxi Dideu Medichem Co. Ltd
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Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
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