4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine Chemical Properties

Melting point:

118.0 to 122.0 °C

Boiling point:

250℃[at 101 325 Pa]

Density 

1.317±0.06 g/cm3(Predicted)

vapor pressure 

0.02Pa at 20℃

storage temp. 

Sealed in dry,Room Temperature

pka

9.49±0.70(Predicted)

form 

powder to crystal

color 

White to Orange to Green

Water Solubility 

61mg/L at 20℃

LogP

2.1 at 25℃

CAS DataBase Reference

89392-03-0(CAS DataBase Reference)

EPA Substance Registry System

Carbamic acid, N-(4,6-dimethoxy-2-pyrimidinyl)-, phenyl ester (89392-03-0)

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

43-51/53

Safety Statements 

24-37-61

RIDADR 

UN 3077 9/PG III

HazardClass 

9

PackingGroup 

III

HS Code 

2933599590

4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine Usage And Synthesis

Chemical Properties

Crystalline Powder

Uses

Intermediate for the production of Sulfonyl Urea herbicides. Product Data Sheet

Flammability and Explosibility

Non flammable

Synthesis

To a stirred solution of 2-amino-4,6-dimethoxypyrimidine (1 g, 6.45 mmol) in acetonitrile (10 mL) was added triethylamine (0.85 g, 8.40 mmol) at room temperature, followed by the slow dropwise addition of phenyl chloroformate (1.31 g, 8.37 mmol). The reaction mixture was heated to 60 °C and stirred for 6 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with water (6 mL), the precipitated solid was collected by filtration and dried under vacuum to afford 2-((phenoxycarbonyl)aminomethyl)-4,6-dimethoxypyrimidine (Compound 6) as a white solid in the following yields: 1.48 g, 83%; melting point: 119 °C; 1H NMR (400 MHz, DMSO-d6): δ 7.65 (s 1H), 7.42-7.40 (m, 2H), 7.18-7.14 (m, 3H), 5.80 (s, 1H), 3.96 (s, 6H); ESI-MS: m/z, 276.1 (M + 1).

References

[1] Asian Journal of Chemistry, 2017, vol. 29, # 7, p. 1477 - 1481

4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine(89392-03-0)Related Product Information

• ALTRENOGEST
• Dimethoxymethane
• 2-Methylsulfonyl-4,6-dimethoxypyrimidine
• 3-Dimethylaminopropylamine
• Glycine
• 4-Dimethylaminobenzaldehyde
• Diphenyldimethoxysilane
• 4-Dimethylaminopyridine
• Betaine
• Dimethyldimethoxysilane
• 1,1-Dimethoxyethane
• 2-Dimethylaminoethanol
• 4,6-Dimethoxypyrimidine
• 4,6-DIMETHOXY-2-(PHENOXYCARBONYL)AMINOPYRIMIDINE(LEVULINICACIDETHYLESTER)
• 4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine
• AMINO ACIDS
• Dimethoxy