Resorantel
Resorantel Basic information
- Product Name:
- Resorantel
- Synonyms:
-
- Pesorantelum
- N-(4-Bromophenyl)-2,6-dihydroxybenzamide
- RESORANTEL
- Benzamide, N-(4-bromophenyl)-2,6-dihydroxy-
- Inhibitor,inhibit,Parasite,Resorantel
- Resorcylicacidlactone
- CAS:
- 20788-07-2
- MF:
- C13H10BrNO3
- MW:
- 308.13
- EINECS:
- 244-040-9
- Mol File:
- 20788-07-2.mol
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Resorantel Chemical Properties
- Melting point:
- 229-230°; mp 183-186° (LeMaire)
- Boiling point:
- 391.1±42.0 °C(Predicted)
- Density
- 1.699±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 250 mg/mL (811.35 mM; Need ultrasonic)
- form
- Solid
- pka
- 7.62±0.35(Predicted)
- color
- White to off-white
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Resorantel Usage And Synthesis
Uses
Resorantel is an anthelmintic[1]. Resorantel is used in the research of paramphistomiasis in cattle and sheep and has also been used for the research of G. aegypticus[2].
in vivo
Resorantel (65 mg/kg, a single oral dose) possesses efficacy against paramphistomiasis in naturally infected sheep[1].
| Animal Model: | Five flocks of sheep in different villages of Haryana[1]. |
| Dosage: | 65 mg/kg. |
| Administration: | A single oral dose. |
| Result: | None of the treated sheep died of enteric paramphistomiasis. The clinical signs disappeared within 2 to 3 days of the treatment and their appetite and general condition improved. No ill effects of the drug were noticed. Of the untreated sheep, 35 % died with a range of 24-52 % in the different flocks. Many of the other untreated sheep continued to exhibit clinical signs of paramphistomiasis. |
References
[1] R P Gupta, et al. Efficacy of resorantel against paramphistomiasis in naturally infected sheep. Trop Anim Health Prod. 1981 Feb;13(1):35-6. DOI:10.1007/BF02237884
[2] Swan GE. The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. J S Afr Vet Assoc. 1999;70(2):61-70. DOI:10.4102/jsava.v70i2.756
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