estriol succinate
estriol succinate Basic information
- Product Name:
- estriol succinate
- Synonyms:
-
- Estra-1,3,5(10)-triene-3,16α,17β-triol 16,17-bis(hydrogen succinate)
- 113-22-4 (Di-hydrochloride salt)
- Einecs 208-185-1
- Estrioli succinas
- Estrioli succinas [inn-latin]
- Estriolo succinato
- Estriolo succinato [dcit]
- Oestriol succinate
- CAS:
- 514-68-1
- MF:
- C26H32O9
- MW:
- 488.53
- EINECS:
- 208-185-1
- Mol File:
- 514-68-1.mol
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estriol succinate Chemical Properties
- Boiling point:
- 716.8±60.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- pka
- 4.40±0.17(Predicted)
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estriol succinate Usage And Synthesis
Originator
Hemostyptanon,Endopancrine,France,1966
Uses
Estrogen.
Definition
ChEBI: Estriol succinate is a steroid ester and a hemisuccinate.
Manufacturing Process
Succinic anhydride and 60 ml of pyridine is heated at 90°C for 4 hours, after which the reaction mixture is poured into water. The aqueous solution is extracted with ether, the ether layer is separated, washed with diluted sulfuric acid and after that with water until neutral, then evaporated to dryness to obtain 14 grams of an amorphous substance. Melting point 82° to 86°C. This drying residue proves to consist of a mixture of estriol disuccinate and estriol monosuccinate, which are separated by repeated crystallization from a mixture of methanol and water.
brand name
Theelol (Parke-Davis).
Therapeutic Function
Estrogen