TAK-020 Chemical Properties

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 16.67 mg/mL (47.44 mM; ultrasonic and warming and heat to 60°C)

form 

Solid

pka

6.41±0.20(Predicted)

color 

White to off-white

TAK-020 Usage And Synthesis

Uses

TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate.

References

[1] Sabat M, et al. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64(17):12893-12902. DOI:10.1021/acs.jmedchem.1c01026

TAK-020(1627603-21-7)Related Product Information

• TAK-659 (hydrochloride)
• Tak-715
• N-Des(aMinocarbonyl) AZ-TAK1 Inhibitor