Nestoron Chemical Properties

Melting point:

178-179°

alpha 

D21 -105° (c = 1.2 in chloroform)

Boiling point:

420.37°C (rough estimate)

Density 

1.0550 (rough estimate)

refractive index 

1.4433 (estimate)

storage temp. 

2-8°C

solubility 

DMSO: soluble5mg/mL, clear

form 

powder

color 

white to beige

InChIKey

CKFBRGLGTWAVLG-GOMYTPFNSA-N

Safety Information

WGK Germany 

3

Nestoron Usage And Synthesis

Uses

Segesterone Acetate has been used to study the: comparison of androgenic and estrogenic properties of progestins used in contraception and hormone therapy; impact on hepatic estrogen-sensitive proteins by 1-yr contraceptive vaginal ring delivering Nestorone and ethinyl estradiol.

Definition

ChEBI: Elcometrine is a corticosteroid hormone.

Pharmacokinetics

Elcometrine is a member of the 19-norprogesterone class of pr ogestins. when administered subcuta neously (implant), intravaginally (vaginal ring), or transdermally, elcometrine is an exceptionally potent progestin. It is 100-fold more potent when administered subcutaneously than when delivered orally. Its oral bioavaiability is only 10%，with a half life of just 1 to 2 hours because of rapid metabolism. The C16 methylene functionality substantially increases its affinity for the progesterone receptor.

Clinical Use

Because of its antiestrogenic action, elcometrine also can be administered transdermally along with estradiol as a treatment for menopausal symptoms .

Nestoron(7759-35-5)Related Product Information

• Diethylstilbestrol
• Testosterone undecanoate
• Medroxyprogesterone Acetate
• Methylene Blue
• Megestrol acetate
• Ethyl acetate
• Sodium acetate
• Hydroxyprogesterone acetate
• 4,4'-Diphenylmethane diisocyanate
• Norgesterone
• Cyproterone acetate
• Methylene Chloride
• ACETATE
• 17a-Hydroxy-19-norpregn-4-ene-3,20-dione
• Gestonoronacetat
• Nestoron
• CI NO 50205