1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE Chemical Properties

Melting point:

71°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Light yellow

InChI

1S/C7H6F2O2S/c1-12(10,11)5-2-3-6(8)7(9)4-5/h2-4H,1H3

InChIKey

WMBJGJXMKCOHGG-UHFFFAOYSA-N

SMILES

Fc1c(ccc(c1)[S](=O)(=O)C)F

Safety Information

HS Code 

2930909899

Storage Class

11 - Combustible Solids

1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE Usage And Synthesis

Uses

1,2-Difluoro-4-methylsulfonylbenzene

Synthesis

Step 1: Synthesis of 1,2-difluoro-4-methanesulfonylbenzene; a mixture of thionyl chloride (12.73 mL, 0.175 mol) and methanesulfonic acid (28.4 mL, 0.438 mol) was heated and refluxed overnight, and subsequently cooled to 80 °C. At this temperature, 1,2-difluorobenzene (8.64 mL, 88 mmol) and trifluoromethanesulfonic acid (0.675 mL, 8.8 mmol) were added dropwise. The reaction mixture was continued to be heated at 120 °C for 3 h, after which it was cooled to room temperature and poured into ice water (200 mL). The mixture was extracted three times with ethyl acetate, the organic extracts were combined and dried over sodium sulfate, filtered and the solvent evaporated. The product was purified by fast chromatography using 15% ethyl acetate/hexane as eluent to afford 1,2-difluoro-4-methylsulfonylbenzene (9.98 g, 59% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ 3.27 (s, 3H), 7.70-7.84 (m, 2H), 8.02-8.09 (m, 1H).

References

[1] Patent: US2009/286812, 2009, A1. Location in patent: Page/Page column 18
[2] Patent: WO2007/54668, 2007, A1. Location in patent: Page/Page column 8-9; 10-11

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