Isoquinolin-4-ol Chemical Properties

Melting point:

223-225℃

Boiling point:

425.4±18.0 °C(Predicted)

Density 

1.26

storage temp. 

Sealed in dry,Room Temperature

solubility 

Deuterated Chloroform, Dichloromethane, Ehtyl Acetate

form 

Solid

pka

5.25±0.40(Predicted)

color 

Off White

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2933499090

Isoquinolin-4-ol Usage And Synthesis

Uses

4-?Isoquinolinol is a metabolite of Isoquinoline (I874930) and has a high anti-radical, hypnotic-sedative and myorelaxant activities. 4-?Isoquinolinol is also an impurity of 1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride (P309050), which is a useful synthetic intermediate in the synthesis of cis-Hydroxy Solifenacin (H953525) and cis-Hydroxy Solifenacin N-Oxide (H953485); both metabolites of Solifenacin (S676700, HCl) which is a muscarinic M3 receptor antagonist and is used in treatment of urinary incontinence.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 1946, 1947 DOI: 10.1021/ja01200a032

Isoquinolin-4-ol(3336-49-0)Related Product Information

• Methyl 2-bromo-3-methylbenzoate
• Benzoic acid, 5-chloro-4-hydroxy-2-methyl-, ethyl ester
• Ethyl 6-bromo-2-fluoro-3-formylbenzoate
• Methyl 2-chloro-3-fluoro-6-methoxybenzoate
• RARECHEM AL BF 0314
• Ethyl 4-chloro-3-hydroxybenzoate
• Ethyl 5-bromo-2-fluoro-3-formylbenzoate
• methyl 2,4-dichloro-6-methylbenzoate
• Methyl-2-bromo-4,5-dimethoxybenzoate
• Ethyl 4-ethoxy-5-fluoro-2-methoxybenzoate
• Ethyl 5-fluoro-4-formyl-2-(trifluoromethyl)benzoate
• Methyl 2-bromo-4-ethoxybenzoate
• Methyl 2-bromo-4-fluoro-3-methoxybenzoate
• Ethyl 4-chloro-2-fluoro-3-hydroxybenzoate
• Methyl 2,6-dichloro-4-ethoxybenzoate
• Ethyl 5-ethoxy-2-fluoro-3-formylbenzoate
• methyl 2,3,5-trichlorobenzoate
• Ethyl 5-fluoro-4-hydroxy-2-methylbenzoate