Losigamone
Losigamone Basic information
- Product Name:
- Losigamone
- Synonyms:
-
- Losigamone
- losigame
- 5-[(2-Chlorophenyl)hydroxymethyl]-4-methoxyfuran-2(5H)-one
- Losigamon
- 2(5H)-Furanone, 5-[(R)-(2-chlorophenyl)hydroxymethyl]-4-methoxy-, (5S)-rel-
- ADD 137022
- ADD137022
- ADD-137022
- CAS:
- 112856-44-7
- MF:
- C12H11ClO4
- MW:
- 254.67
- Mol File:
- 112856-44-7.mol
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Losigamone Chemical Properties
- Boiling point:
- 480.1±45.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- pka
- 12.32±0.20(Predicted)
- form
- Solid
- color
- White to off-white
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Losigamone Usage And Synthesis
Uses
Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates the neuronal chloride channel and enhance chloride influx. Losigamone potentiates GABA-mediated responses and reduces epileptiform activity induced by chloride channel antagonists. Losigamone can be used for epilepsy research[1][2].
References
[1] Chen H, et al. Losigamone add-on therapy for focal epilepsy. Cochrane Database Syst Rev. 2019 Dec 11;12(12):CD009324. DOI:10.1002/14651858.CD009324.pub5
[2] Jones FA, et al. The anticonvulsant effects of the enantiomers of losigamone. Br J Pharmacol. 1999 Nov;128(6):1223-8. DOI:10.1038/sj.bjp.0702919
LosigamoneSupplier
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