Dibenamine
Dibenamine Basic information
- Product Name:
- Dibenamine
- Synonyms:
-
- Dibenamine
- N,N-dibenzyl-2-chloroethanamine
- (2-Chloroethyl)dibenzylamine
- N,N-Dibenzyl-2-chloroethan-1-amine
- SKF 199
- 2-chloro-N,N-bis(phenylmethyl)ethanamine
- bis(benzyl)-(2-chloroethyl)amine
- Benzenemethanamine, N-(2-chloroethyl)-N-(phenylmethyl)-
- CAS:
- 51-50-3
- MF:
- C16H18ClN
- MW:
- 259.77
- Mol File:
- 51-50-3.mol
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Dibenamine Chemical Properties
- Melting point:
- 192 °C
- Boiling point:
- 407.11°C (rough estimate)
- Density
- 1.0738 (rough estimate)
- refractive index
- 1.6000 (estimate)
- pka
- 6.50±0.50(Predicted)
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Safety Information
- Hazardous Substances Data
- 51-50-3(Hazardous Substances Data)
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Dibenamine Usage And Synthesis
Uses
Dibenamine is an alpha-adrenergic antagonist that exhibits the ability to block both basal and histamine-stimulated gastric acid secretion, making it therapeutically relevant in conditions involving excessive gastric acid production.
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Can cause leukopenia (reduced whte blood cell count). Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl and NOx. See also AROMATIC MINES.
References
[1] The affinity and selectivity of α-adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D-adrenoceptors DOI:10.1002/prp2.602