GYKI 53405
GYKI 53405 Basic information
- Product Name:
- GYKI 53405
- Synonyms:
-
- GYKI 53405
- LY 293606
- 1-[5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
- Ethanone, 1-[5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-7-yl]-
- CAS:
- 143691-37-6
- MF:
- C19H19N3O3
- MW:
- 337.37
- Mol File:
- 143691-37-6.mol
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GYKI 53405 Usage And Synthesis
Description
GYKI-53405, also known as LY 293606, is a noncompetitive AMPA receptor antagonist. GYKI-53405 binds specifically to Xenopus brain membranes with KD and Bmax values of 4.5 microM and 35 pmol mg-1 protein respectively. Binding is increased in the presence of Mg2+ and is unaffected by AMPA or kainate.