lyngbyatoxin B
lyngbyatoxin B Basic information
- Product Name:
- lyngbyatoxin B
- Synonyms:
-
- lyngbyatoxin B
- 3H-Pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one, 9-(1-ethenyl-4-hydroxy-1,5-dimethyl-5-hexenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)- (9CI)
- CAS:
- 133084-52-3
- MF:
- C27H39N3O3
- MW:
- 453.62
- Mol File:
- 133084-52-3.mol
lyngbyatoxin B Usage And Synthesis
Description
Lyngbyatoxin B is an irritant form Lyngbya majuscula.
Uses
Lyngbyatoxin B is a complex compound in a versatile biosynthetic pathway from the marine cyanobacterium Moorea producens. By heterologously expressing the lyngbyatoxin biosynthetic pathway in Escherichia coli, lyngbyatoxin A (25.6 mg/L) and its precursor indolactam-V (150 mg/L) were successfully produced. This approach confirmed the biosynthetic route of lyngbyatoxin and laid a chemical foundation for future pathway engineering. In addition, the successful production of lyngbyatoxin A in E. coli opens the possibility for heterologous expression and characterization of other cyanobacterial natural products.
References
[1] High-Titer Heterologous Production in E. coli of Lyngbyatoxin, a Protein Kinase C Activator from an Uncultured Marine Cyanobacterium