TA-03 Chemical Properties

Melting point:

212-213 °C

Boiling point:

443.1±45.0 °C(Predicted)

Density 

1.202±0.06 g/cm3(Predicted)

pka

9.70±0.20(Predicted)

TA-03 Usage And Synthesis

Uses

7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM, and can be used for the research of Alzheimer's disease (AD)[1].

IC 50

hAChE: 10.5 μM (IC₅₀); hBCHE: 21 μM (IC₅₀)

References

[1] Spilovska K, et al. 7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies. Molecules. 2013;18(2):2397-2418. Published 2013 Feb 20. DOI:10.3390/molecules18022397

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