thrazarine
thrazarine Basic information
- Product Name:
- thrazarine
- Synonyms:
-
- thrazarine
- Antibiotic FR-900840
- FR-900840
- O-[(R)-2-Diazo-3-hydroxy-1-oxobutyl]-L-serine
- CAS:
- 120128-14-5
- MF:
- C7H11N3O5
- MW:
- 217.18
- Mol File:
- 120128-14-5.mol
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thrazarine Chemical Properties
- Melting point:
- 123-125 °C
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thrazarine Usage And Synthesis
Uses
Thrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research[1].
References
[1] Kameyama T, et al. Thrazarine, a new antitumor antibiotic. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo). 1988 Nov;41(11):1561-7. DOI:10.7164/antibiotics.41.1561