LG 6-102
LG 6-102 Basic information
- Product Name:
- LG 6-102
- Synonyms:
-
- LG 6-102
- LG 6102,LG 6 102
- CAS:
- 132798-30-2
- MF:
- C22H29NO3.ClH
- MW:
- 391.936
- Mol File:
- 132798-30-2.mol
LG 6-102 Usage And Synthesis
Description
LG 6-102 is a new propafenone-related antiarrhythmic agent with good oral activity in rats.
in vivo
Rats were treated with LG 6-101 (16, 32, 64, 128, 256 mg kg-1 bodyweight), LG 6-102 (4, 8, 16, 32, 64 mg kg-1 bodyweight) and propafenone (32, 64, 128, 256 mg kg-1 bodyweight) by gavage twice daily during 4 days. Both, LG 6-101 and LG 6-102 showed strong antiarrhythmic effects against arrhythmias induced on the fifth day by infusion of aconitine (10 micrograms kg-1 min-1). LG 6-102 was significantly more effective against cardiac arrest caused by infusion of aconitine (P less than or equal to 0.05) than LG 6-101._x000D_ _x000D_ Reference: Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. https://pubmed.ncbi.nlm.nih.gov/1620247/
target
LG 6-102 is a new propafenone-related antiarrhythmic agent with good oral activity in rats.