ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > 3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione
3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione
3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione Basic information
- Product Name:
- 3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione
- Synonyms:
-
- 3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione
- CRBN ligand-148
- 2,6-Piperidinedione, 3-(4-bromo-2,6-dichlorophenyl)-
- CAS:
- 3036607-19-6
- MF:
- C11H8BrCl2NO2
- MW:
- 337
- Mol File:
- 3036607-19-6.mol
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3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione Chemical Properties
- Boiling point:
- 441.855±45.00 °C(Press: 760.00 Torr)(predicted)
- Density
- 1.687±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- pka
- 10.706±0.40(predicted)
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3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione Usage And Synthesis
Uses
CRBN ligand-148 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.
IC 50
Cereblon
References
[1] Mileti N, et al. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20(2):507-521. DOI:10.1021/acschembio.4c00812
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