(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride
(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Basic information
- Product Name:
- (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride
- Synonyms:
-
- (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride
- Rotigotine hydrochloride
- (6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenolhydrochloride
- (S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride
- (6S)-
- 8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]-
- CEXBONHIOKGWNU-NUDVEOEASA-N
- rotigotine HCl
- CAS:
- 125572-93-2
- MF:
- C19H26ClNOS
- MW:
- 351.93
- EINECS:
- 603-080-0
- Product Categories:
-
- APIs
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- API
- Mol File:
- 125572-93-2.mol
(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Chemical Properties
- Melting point:
- 114-117°C
- Density
- 1.2g/cm3 at 20℃
- vapor pressure
- 0-0Pa at 20-25℃
- storage temp.
- room temp
- solubility
- Acetone (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)
- form
- solid
- color
- white to off-white
- Stability:
- Hygroscopic
- LogP
- 3.1 at 20℃ and pH7
- Surface tension
- 72.3mN/m at 1g/L and 20℃
(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochloride Usage And Synthesis
Chemical Properties
White to Off-White Solid
Uses
It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.
Biochem/physiol Actions
Rotigotine is a dopamine receptor agonist with preference for D3 receptors over D2 and D1. As such, it is an effective anti-Parkinsonian agent. Racemic rotigotine is about 50 times as potent as quinpirole, the gold standard D2 agonist.
in vivo
In primed rats, Rotigotine (N-0923) (0.035, 0.1 and 0.35 mg/kg) induces contralateral turning behavior in a dose dependent manner. In drug naive rats, the turning behavior induced by Rotigotine, either alone or in combination with SCH 39166, is reduced compared to primed rats[3].
IC 50
D3 Receptor: 0.71 nM (Ki); D2 Receptor: 4-15 nM (Ki); D5 Receptor: 4-15 nM (Ki); D4 Receptor: 4-15 nM (Ki); D1 Receptor: 83 nM (Ki); α1A: 176 nM (Ki); α1B: 273 nM (Ki); α2A: 338 nM (Ki); α2B: 27 nM (Ki); 5-HT1A Receptor: 30 nM (Ki); 5-HT7 Receptor: 86 nM (Ki)
storage
room temperature (desiccate)
(6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol hydrochlorideSupplier
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