3,3-DIMETHYL-PIPERIDIN-4-ONE HCL SALT Chemical Properties

storage temp. 

Inert atmosphere,Room Temperature

Appearance

Off-white to yellow Solid

Safety Information

HS Code 

2933399990

3,3-DIMETHYL-PIPERIDIN-4-ONE HCL SALT Usage And Synthesis

Synthesis

General procedure for the synthesis of 3,3-dimethylpiperidin-4-one hydrochloride using 1-BOC-3,3-dimethyl-4-oxopiperidine as starting material: 1-BOC-3,3-dimethyl-4-oxopiperidine (2.0 g, 8.8 mmol) was dissolved in THF (30 mL) and concentrated hydrochloric acid (1.5 mL) was added slowly. The reaction mixture was stirred at room temperature and subsequently heated to 60 °C and maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and white precipitate formation was observed. The precipitate was collected by filtration and dried to give 3,3-dimethylpiperidin-4-one hydrochloride (1.1 g, 78% yield). The product did not require further purification and could be used directly in the subsequent reaction.

References

[1] Patent: US2012/220629, 2012, A1. Location in patent: Page/Page column 45
[2] Patent: WO2012/113103, 2012, A1. Location in patent: Page/Page column 61
[3] Patent: WO2017/189386, 2017, A1. Location in patent: Page/Page column 44
[4] Patent: WO2018/136887, 2018, A1. Location in patent: Page/Page column 154

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