2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE
2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE Basic information
- Product Name:
- 2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE
- Synonyms:
-
- BU 224 HYDROCHLORIDE
- 2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE
- Quinoline, 2-(4,5-dihydro-1H-imidazol-2-yl)-
- CAS:
- 187173-05-3
- MF:
- C12H11N3
- MW:
- 197.24
- Mol File:
- 187173-05-3.mol
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2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE Chemical Properties
- Boiling point:
- 372.9±34.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- solubility
- ethanol: 1.2 mg/mL
- form
- solid
- pka
- 9.87±0.40(Predicted)
- color
- white
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MSDS
- Language:English Provider:SigmaAldrich
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2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE Usage And Synthesis
Uses
BU224 is one of the two most widely studied I2 receptor ligands and have antinociceptive and antidepressant-?like activities in rodents.
Biological Activity
High affinity ligand for the imidazoline I 2 binding site (K i = 2.1 nM). Putative I 2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.