(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone
(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone Basic information
- Product Name:
- (16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone
- Synonyms:
-
- (16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone
- Physalin A
- 1,17:2,6-Dimethano-8H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,19(1H,8aH)-tetrone, 2,3,6,6a,9,10,10a,10b,14,16,16a,17-dodecahydro-8a,16,17-trihydroxy-2,6a,10b-trimethyl-3-methylene-, (1S,2S,6R,6aS,8aR,10aS,10bR,16R,16aS,17R,18aR)-
- CAS:
- 23027-91-0
- MF:
- C28H30O10
- MW:
- 526.5318
- Mol File:
- 23027-91-0.mol
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(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone Chemical Properties
- Boiling point:
- 838.3±65.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- pka
- 9.82±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- VELDODQHYQSJOF-RKWIMMEGSA-N
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(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone Usage And Synthesis
Uses
Physalin A is a bioactive withanolide which induces apoptosis via p-53-Noxa-mediated ROS generation.
in vivo
Physalin A (40-80 mg/kg; Intraperitoneal injection; 10 days) has antitumor effect in H292 xenograft tumor model[3].
Physalin A (2 μL 20 μM; Injection of nucleus pulposus of the disc; Single dose) has a protective effect in a rat model of disc degeneration[4].
| Animal Model: | Male BALB/c mice[3] |
| Dosage: | 40 and 80 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); 10 days |
| Result: | Significantly reduced the mean tumor volume and tumor weight, had the least effect on the weight of mice. Decreased Tyr705-p-STAT3 levels, and increased caspase-3 activation. |
| Animal Model: | Male Sprague-Dawley rats aged 6-8 weeks old (220±20 g) with intervertebral disc degeneration[4] |
| Dosage: | 2 μL 20 μM |
| Administration: | Injection of nucleus pulposus of the disc; Single dose |
| Result: | Alleviated disc degradation. Reduced inflammation and fibrosis. |
(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactoneSupplier
Wuhan ChemFaces Biochemical Co., Ltd.
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- 18607101326 15172504745
- aileen@chemfaces.com
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
- 3008007409@qq.com
Chengdu Push Bio-Technology Co., Ltd.
- Tel
- 028-028-85370565-229-229 18080489829
- 18080489829@163.com
Shanghai Standard Technology Co.,Ltd.
- Tel
- 021-021-57127007-6622-6622 17621252073
- luzh@nature-standard.com
Nanjing Digger Medical Technology Co. Ltd.
- Tel
- 025-025-51191215 18013836722
- 2399235533@qq.com
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(16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone(23027-91-0)Related Product Information
- (16β,22R)-14α,17-Epoxy-13,14,20,22-tetrahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone
- physalin F
- Physalin G
- physalin B
- (13S,14R,22R,25S)-1,15-Dioxo-5-chloro-6β,13,20,22-tetrahydroxy-14,17α:14,27-diepoxy-16β,24-cyclo-13,14-seco-5α-ergosta-2-ene-18,26-dioic acid 18,20:26,22-dilactone
- 1,17:2,6-Dimethano-8H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,19(1H,8aH)-tetrone, 2,3,6,6a,9,10,10a,10b,14,16,16a,17-dodecahydro-8a,16,17-trihydroxy-2,3,6a,10b-tetramethyl-, (1S,2S,3S,6R,6aS,8aR,10aS,10bR,16R,16aS,17R,18aR)-
- PHYSALIN D