N,N-DIMETHYL-4-(5-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BENZENAMINE Chemical Properties

Melting point:

209.5-211.0 °C

Boiling point:

459.3±47.0 °C(Predicted)

Density 

1.170±0.06 g/cm3(Predicted)

pka

11.85±0.10(Predicted)

N,N-DIMETHYL-4-(5-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BENZENAMINE Usage And Synthesis

Uses

V-161 is the orally active inhibitor for Na+-V-ATPase with an IC50 of 144 nM. V-161 inhibits Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline condition with MIC of 4 μg/mL and 4 μg/mL. V-161 inhibits colonization of VRE in mouse small intestine[1].

References

[1] Suzuki K, et al., Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure. Nat Struct Mol Biol. 2024 Nov 21. DOI:10.1038/s41594-024-01419-y

N,N-DIMETHYL-4-(5-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BENZENAMINE(69570-95-2)Related Product Information

• N,N-DIMETHYL-4-(5-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BENZENAMINE
• [4-(1H-IMIDAZOL-2-YL)-PHENYL]-DIMETHYL-AMINE
• 2-(P-N,N-DIMETHYLAMINOPHENYL)-1H-BENZOIMIDAZOLE
• 4-(5-METHYL-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE
• 2-(4-Dimethylaminophenyl)-1H-benzimidazole-5-carboxylic acid