4-BROMO-2-THIOPHENECARBOXAMIDE Chemical Properties

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Appearance

White to off-white Solid

Safety Information

Risk Statements 

43

Safety Statements 

36/37

HazardClass 

IRRITANT

4-BROMO-2-THIOPHENECARBOXAMIDE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 4-bromothiophene-2-carboxamide from the compound (CAS: 31767-01-8) is as follows: in a 25 mL round-bottomed flask equipped with a magnetic stirrer, aldoxime (5 mmol), copper(II) acetate (45 mg, 0.25 mmol), acetonitrile (10 mg, 0.25 mmol), and ethanol (15 mL) were added in sequence. The reaction mixture was stirred for 4-8 hours at 78 °C or 12 hours at room temperature. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was purified by column chromatography to afford the target compound 4-bromothiophene-2-carboxamide.

References

[1] RSC Advances, 2016, vol. 6, # 43, p. 37093 - 37098
[2] Journal of Chemical Research, 2016, vol. 40, # 10, p. 594 - 596
[3] Bulletin de la Societe Chimique de France, 1967, p. 4115 - 4120

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