3-BROMO-5-CHLOROPHENYLAMINE Chemical Properties

Melting point:

41-45°

Boiling point:

284.1±20.0 °C(Predicted)

Density 

1.722±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.47±0.10(Predicted)

form 

solid

color 

Light brown to brown

InChI

InChI=1S/C6H5BrClN/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2

InChIKey

YYBRLVWWPRAQDX-UHFFFAOYSA-N

SMILES

C1(N)=CC(Cl)=CC(Br)=C1

Safety Information

Hazard Codes 

Xi

RIDADR 

2018

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

2921420090

3-BROMO-5-CHLOROPHENYLAMINE Usage And Synthesis

Uses

3-Bromo-5-chloroaniline is a reactant in the preparation of triazolophthalazines as inhibitors of diverse bromodomains

Synthesis

2. 5kg 3,4,5_trifluorophenol crude, of which toluene content is 2%, the content of near-boiling impurity 3,5_difluorophenol is 0. 05%, 3,4-difluorophenol content is 0. 03%, 2,4-difluorophenol content is 0. 025%, 2,3,5-trifluorophenol content is 0. 07%, 2, 3,4-trifluorophenol content is 0. 042%, 2,4,6-trifluorophenol content is 0. 01%. The content of 2,3,4-trifluorophenol was 0. 042%, 2,4,6-trifluorophenol was 0. 01 %, and the content of 3,4,5-trifluorophenol was 97.8%.

The crude material was put into a 5L distillation kettle, and p-tert-butyltoluene was added 1.5kgo to 100mmHg full reflux Ihr, and then p-tert-butyltoluene fraction was collected from the top of the tower at a reflux ratio of 1 ?? 1. After the collection, the tower kettle sampling GC analysis, toluene content is not detected, 3,5- difluorophenol contains 50ppm, 3,4- difluorophenol 62ppm, 2,4- difluorophenol 2ppm, 2,3,5-trifluorophenol 3ppm, 2,3,4-trifluorophenol 2ppm, will be evaporated from the top of the tower to get the high-purity 3,4,5-trifluorophenol weighing 2.2kg, content of 99.98%, distillation yield of 99.9%, distillation yield of 1:1 reflux ratio. . 98 %, and the distillation yield was 89. 97 %.

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