Boc-NH-PEG10-CH2CH2COOH
Boc-NH-PEG10-CH2CH2COOH Basic information
- Product Name:
- Boc-NH-PEG10-CH2CH2COOH
- Synonyms:
-
- Boc-NH-PEG10-CH2CH2COOH
- BocNH-PEG10-COOH
- BocNH-PEG10-C2-COOH
- CAS:
- 2410598-01-3
- MF:
- C28H55NO14
- MW:
- 629.74
- Mol File:
- 2410598-01-3.mol
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Boc-NH-PEG10-CH2CH2COOH Chemical Properties
- Boiling point:
- 683.5±55.0 °C(Predicted)
- Density
- 1.121±0.06 g/cm3(Predicted)
- pka
- 4.28±0.10(Predicted)
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Boc-NH-PEG10-CH2CH2COOH Usage And Synthesis
Biological Activity
Boc-NH-PEG10-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Boc-NH-PEG10-CH2CH2COOHSupplier
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