3-Quinolinecarboxaldehyde, 6-broMo- Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Light yellow to green yellow Solid

InChI

InChI=1S/C10H6BrNO/c11-9-1-2-10-8(4-9)3-7(6-13)5-12-10/h1-6H

InChIKey

PCHCYMZZDAUVQB-UHFFFAOYSA-N

SMILES

N1C2C(=CC(Br)=CC=2)C=C(C=O)C=1

3-Quinolinecarboxaldehyde, 6-broMo- Usage And Synthesis

Synthesis

General procedure for the synthesis of 6-bromoquinoline-3-carbaldehyde from (6-bromoquinolin-3-yl)methanol: (6-bromoquinolin-3-yl)methanol (716 mg, 2.70 mmol) was dissolved in dichloromethane (9 mL), manganese dioxide (705 mg, 8.12 mmol) was added, and the reaction was stirred at 20°C for 2 days. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford the target product 6-bromoquinoline-3-carbaldehyde (577 mg, 63% yield).

References

[1] Patent: WO2011/131741, 2011, A1. Location in patent: Page/Page column 92
[2] Patent: US2012/94976, 2012, A1. Location in patent: Page/Page column 58

3-Quinolinecarboxaldehyde, 6-broMo-(1196155-68-6)Related Product Information

• 6-BROMO-2(1H)-QUINOLONE
• 6-Bromoquinazoline
• 6-BroMoquinoline-3-carbonitrile
• 6-bromoquinoxalin-2-amine
• 6-BROMO-QUINAZOLIN-4-YLAMINE
• 6-BroMoquinoline-2-carbaldehyde
• 6-BROMOQUINOLINE-3-CARBOXYLIC ACID
• 6-BroMoquinolin-3-aMine
• 6-Bromogramine
• ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE
• 6-bromoquinoxalin-2(1H)-one