AMT HYDROCHLORIDE
AMT HYDROCHLORIDE Basic information
- Product Name:
- AMT HYDROCHLORIDE
- Synonyms:
-
- 5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZIN-2-AMINE, HYDROCHLORIDE
- AMT HYDROCHLORIDE
- AMT HCL
- 2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HYDROCHLORIDE
- 2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HCL
- 4H-1
- 4H-1,3-Thiazin-2-amine, 5,6-dihydro-6-methyl-, hydrochloride (1:1)
- CAS:
- 21463-31-0
- MF:
- C5H10N2S.ClH
- MW:
- 166.67
- Mol File:
- 21463-31-0.mol
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AMT HYDROCHLORIDE Chemical Properties
- Melting point:
- 146-150°C
- storage temp.
- 0-6°C
- solubility
- DMF: >8 mg/ml; DMSO: >16 mg/ml; Ethanol: >25 mg/ml; Water: >25 mg/ml
- form
- A crystalline solid
- Water Solubility
- Soluble to 10 mM in water
MSDS
- Language:English Provider:ACROS
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AMT HYDROCHLORIDE Usage And Synthesis
Description
AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations; the IC50 values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.
Chemical Properties
white to off-white powder
Uses
AMT Hydrochloride is a potent and selective inhibitors of inducible nitric oxide synthase, which may lead to therapeutic applications in the treatment of inflammatory and autoimmune diseases.
Biological Activity
Potent, selective and reversible inhibitor of iNOS (IC 50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).
storage
Desiccate at +4°C
AMT HYDROCHLORIDESupplier
Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel
- 021-61259108 18621169109
- market03@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Shanghai Synmedia Chemical Co., Ltd.
- Tel
- 021-38681880 13817889927
- sales@synmedia-chem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
EMMX Biotechnology LLC
- Tel
- 888-539-0666
- info@emmx.com