9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE
9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE Basic information
- Product Name:
- 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE
- Synonyms:
-
- 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE
- PROSTAGLANDIN F2ALPHA 1,11-LACTONE
- 9,11,15-trihydroxy-,iota-lactone,(5z,9-alpha,11-prosta-13-dien-1-oicacid
- pgf2-alpha1,11-lactone
- Brn 5596377
- Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, iota-lactone, (5Z,9-alpha,11-alpha,13E,15S)-
- Prostaglandin F2α 1,11-lactone
- (1R,3Z,10R,12S,13R)-12-hydroxy-13-[(E,3S)-3-hydroxyoct-1-enyl]-9-oxabicyclo[8.2.1]tridec-3-en-8-one
- CAS:
- 62410-84-8
- MF:
- C20H32O4
- MW:
- 336.47
- Mol File:
- 62410-84-8.mol
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9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF: >20 mg/ml; DMSO: >10 mg/ml; Ethanol: >100 mg/ml; Ethanol:PBS (30:70): 8 mg/ml; PBS pH 7.2: <50 μg/ml
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9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONE Usage And Synthesis
Uses
Prostaglandin F2α 1,11-lactone is a prostaglandin. Prostaglandin F2α 1,11-lactone is absorbed by the eye. Prostaglandin F2α 1, 11-Lactone has metabolic stability on the corneal surface and conjunctiva. Prostaglandin F2α 1,11-lactone can be used in the treatment of glaucoma [1].
References
[1] Chien DS, et al. Ocular penetration and bioconversion of prostaglandin F2alpha prodrugs in rabbit cornea and conjunctiva. J Pharm Sci. 1997 Oct;86(10):1180-6. DOI:10.1021/js950373b
9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,11-LACTONESupplier
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