4-(TRIFLUOROMETHOXY)BENZYLAMINE Chemical Properties

Boiling point:

57-60 °C10 mm Hg(lit.)

Density 

1.252 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.452(lit.)

Flash point:

172 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.75±0.10(Predicted)

form 

Liquid

Specific Gravity

1.252

color 

Clear colorless to light yellow

Sensitive 

Air Sensitive

BRN 

8200624

CAS DataBase Reference

93919-56-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

RIDADR 

UN2735

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

III

HS Code 

29222990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-(TRIFLUOROMETHOXY)BENZYLAMINE Usage And Synthesis

Chemical Properties

clear colorless to light yellow liquid

Uses

4-(Trifluoromethoxy)benzylamine may be used in chemical synthesis.

Synthesis

A tetrahydrofuran (30 mL) solution of 4-(trifluoromethoxy)benzyl cyanide (5.0 g, 26.72 mmol) was slowly added dropwise to a tetrahydrofuran (30 mL) solution of lithium aluminum tetrahydroxide (3.0 g, 88.44 mmol) at 0 °C. After the dropwise addition was completed, the reaction mixture was warmed to room temperature and stirred for 3 hours. Upon completion of the reaction, the mixture was cooled to 4 °C and diluted with tetrahydrofuran (50 mL). Subsequently, the reaction was quenched by sequentially adding water (3 mL), 15% sodium hydroxide solution (3 mL) and water (3 mL). After quenching, the mixture was stirred at room temperature for 15 minutes. The mixture was filtered through diatomaceous earth and the filtrate was dried with anhydrous magnesium sulfate. Finally, the filtrate was concentrated under reduced pressure to give 4-(trifluoromethoxy)benzylamine (3.1 g, 61% yield).

References

[1] Patent: WO2017/139414, 2017, A1. Location in patent: Paragraph 00215-00216

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