1-PALMITOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE(SODIUM SALT) Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: <.05 mg/ml; DMSO: <.05 mg/ml; Ethanol: <.05 mg/ml

form 

A crystalline solid

1-PALMITOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE(SODIUM SALT) Usage And Synthesis

Description

1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of Pseudomonas aeruginosa, a pathogen associated with pulmonary disease and pneumonia, via binding both Ca²⁺ and Mg²⁺.

Uses

(2R)-2-Hydroxy-3-(phosphonooxy)propyl hexadecanoate Sodium Salt is used in the test kit for screening colorectal adenoma.