4-CYCLOHEXYLMETHOXY-2,6-DIAMINO-5-NITROSOPYRIMIDINE
4-CYCLOHEXYLMETHOXY-2,6-DIAMINO-5-NITROSOPYRIMIDINE Basic information
- Product Name:
- 4-CYCLOHEXYLMETHOXY-2,6-DIAMINO-5-NITROSOPYRIMIDINE
- Synonyms:
-
- NU6027
- 4-CYCLOHEXYLMETHOXY-2,6-DIAMINO-5-NITROSOPYRIMIDINE
- MF:
- C11H17N5O2
- MW:
- 251.28
- Mol File:
- Mol File
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4-CYCLOHEXYLMETHOXY-2,6-DIAMINO-5-NITROSOPYRIMIDINE Chemical Properties
- Melting point:
- 252.5-253.7 °C(lit.)
- storage temp.
- 2-8°C
- solubility
- DMSO: 15 mg/mL
- color
- lavender
MSDS
- Language:English Provider:SigmaAldrich
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4-CYCLOHEXYLMETHOXY-2,6-DIAMINO-5-NITROSOPYRIMIDINE Usage And Synthesis
Uses
NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors